Saturday, March 30, 2013

Kristen Bell, Dax Shepard welcome baby girl

David Livingston / Getty Images file

Dax Shepard and Kristen Bell.

By Kurt Schlosser, TODAY

Actress Kristen Bell and actor Dax Shepard are the parents of a new baby girl, the "Parenthood" star announced on Twitter Thursday.

"Lincoln Bell Shepard is here. She has mom's beauty and dad's obsession with breasts. Hooray!!!" Shepard tweeted.

This is the first child for the couple who co-starred in 2010's "When in Rome." The couple got engaged?in 2009 and had said they were waiting until gay marriage was legal in California before they would marry. But Shepard, 38, did refer to Bell, 32, as his wife in a blog post about his dying father that went viral last week.

Related content:

Source: http://todayentertainment.today.com/_news/2013/03/28/17505216-kristen-bell-and-dax-shepard-welcome-baby-girl?lite

warren sapp i robot the big c

Thursday, March 28, 2013

Tigers have AL Central by the tail

For the past few days?we?ve been previewing the 2013 season. Here, in handy one-stop-shopping form, is our package of previews from the American League Central.

It?s the Tigers? world and everyone else is living in it. Of course we thought that last year too and Detroit didn?t truly wrest control of the AL Central until the last couple weeks of the season. ?This year, however, we feel like that won?t be a problem.

The Indians have a whole new look with Nick Swisher, Michael Bourn and Terry Francona, but do they have enough pitching to challenge for the wild card?

The White Sox were in the race all year in 2012, but with few offseason additions and aging sluggers, is there another season of contention left?

The Royals had the best spring training record of anyone, but does that and fifty cents get them anything more than a bag of chips?

The Twins: another year in the cellar seems unavoidable, but is there any hope at all?

Below are our team-by-team previews for the AL Central as well as our HBT Extra feature on the division. Enjoy.

Source: http://hardballtalk.nbcsports.com/2013/03/28/2013-preview-the-american-league-central/related/

nfl scores nfl scores Devon Walker Tom Cruise ryan reynolds Star Trek: The Original Series Carlton

Thursday, March 14, 2013

6 tips for marketing your book online ? Kobo Writing Life

by Rob Tucker, Co-founder at ReadWave

In the current publishing climate, writers (whether published or self-published) are increasingly responsible for their own marketing. For the last four years I?ve been running an online digital publishing platform which we?ve recently rebranded as ReadWave,that aims to help writers build up a readership online. During that time I?ve had access to a lot of data on what people read online, when they read, and most importantly, why some writers are successful in getting readers and others aren?t. Here are some of the key insights that I?ve learned over the last four years, which hopefully will help you plan a marketing strategy for your writing.

1) The Importance of Short Stories?(even for novelists)

Even if your eventual goal is to sell your novel, start by writing some great short stories and hosting them as free giveaways online. If you?re not yet a well-known author, then readers are 300 times more likely to read a short story of yours rather than the first chapter of a novel. When it comes to online reading, try to keep your stories under 1,500 words as these get by far the most traction.

2) The Limitations of Personal Websites
When most writers decide to market their writing, they usually start by building their own website. If you decide to make your own website the centre of your marketing campaign you?re going to come up against some fairly large problems. Not only is getting people to visit your website extremely difficult, but normally people visiting your site will look around for a few minutes and then leave, never coming back again. You need to RETAIN your visitors and keep them coming back again and again. One solution would be to put a newsletter sign up form on your website (I would recommend MailChimp if you decide to go for this route) but you might be disappointed with the result ? getting newsletter sign ups is hard. A better option is to make one of your social networks the centre of your marketing campaign; that means your Facebook, Twitter, GoodReads or ReadWave page. If you decide to make your Facebook page the centre of your marketing campaign then have a go at building your website on Facebook itself using the Static HTML app. There are plenty of?guides?on how to do this yourself if you?re a bit tech-savvy (it might be easier than you think!), otherwise hire a pro. You can even set it up so that readers get a free giveaway if they ?like? your Facebook page. This will be much more effective than driving traffic to your personal website.

3) Building a Mailing List
Every writer needs a database of the names and email addresses of their grassroots supporters, and whether you?ve written anything new this month or not, you need to keep those supporters engaged every month through newsletters. Really you should put the same time and effort into writing your newsletters as you do in writing your stories. Building a mailing list is difficult, there?s no doubt about it. After speaking to lots of writers, we decided to make newsletters a built-in feature at ReadWave since at the moment there are almost no services that are specifically geared towards helping writers get more sign-ups. A word of warning though, beginners at email marketing tend to get a bit scared by sending out thousands of emails in one go and compensate for this by being stiff, or even worse, sounding corporate. If you do this, people will very quickly unsubscribe. It?s better to send out no newsletter than a bad newsletter. Be funny and easy to approach in your newsletters. Think of it as a chance to build a positive brand around yourself, rather than to sell, sell, sell.

4) A Picture Is Worth A Thousand Words
When it comes to digital content, pictures really are key. Readers are more than five times more likely to start reading stories with interesting pictures than those without. It?s also worth noting that the peak time for online reading is mid-week when people are bored at work. This means that readers don?t want to be seriously engaged with your magnum opus, they just want to flick through something that is quick and easy to read whilst their boss isn?t looking. Think about your online and offline content as two fundamentally different things; online content is very much about surface values. Readers won?t have a lot of time to ponder the hidden depths of your story.

5) Embedding and Linking

The more times a link to your story appears online the better your Google ranking will be, so you should openly share the link to your free online content in as many places as possible. Social networks like Facebook and Twitter are a no-brainer, but try to be more creative, think of other blogs and online communities where you might share your link. At ReadWave we?re building an embedding service to help out with this, which means that you can post your story onto blogs and other websites in exactly the same way that you can post a YouTube video. If you?re approaching bloggers to try to get them to post up your story then take the time to actually get to know them, read their blogs, write some comments on their previous blog entries, sign up to their mailing list. Online marketing operates on a?favor?for?favors?system, so be generous and you shall receive.

6) Self-promote
Finally I just wish to comment on a strange writer?s affliction that I?ve noticed time and time again whilst running ReadWave. Whereas musicians and artists have no problem shamelessly promoting themselves, the majority of writers tend to be fairly conservative about getting their name out there, as though marketing is too vulgar for them. Often it?s simply a lack of confidence. Whether it?s a colleague; a friend of friend; or just a stranger that you got chatting to, every single person you?ve ever met or will ever meet is potentially a part of your fanbase. This is how marketers think and, without being pushy about it,?you should try to embrace that philosophy as much as you can. Don?t be shy.
Best of luck to you all in building your readership, and if you have any questions you can contact me at:

rob[at]readwave[dot]com
Join us on Facebook

@readwave

Like this:

Like Loading...

Source: http://kobowritinglife.com/2013/03/13/6-tips-for-marketing-your-book-online/

tour de france

Wednesday, March 13, 2013

Local chemotherapy has a stronger effect on reducing tumor growth, research suggests

Mar. 13, 2013 ? Reducing the growth of a tumor by localized delivery of cancer medication can be achieved by using a combination of ultrasound, temperature-sensitive nanoparticles and MRI. This is shown by Mariska de Smet in her PhD research at Eindhoven University of Technology (TU/e) and Philips Research. Her preclinical studies show that this local chemotherapy is more effective in reducing tumor growth than regular chemotherapy. In addition, the amount of medication reaching the tumor can be measured by adding an imaging marker to the chemo. De Smet defends her thesis on Thursday March 14th.

Using chemotherapy to treat cancer always has unpleasant side effects. The toxic effects of the medication also affect healthy cells, as well as those of the tumor itself. This leads to symptoms like nausea, hair loss or reduced effectiveness of the immune system. Scientists have been working for many years on image-guided administration of medication using 'delivery vehicles': particles that transport the medication through the body to the tumor, which can be imaged after drug release. This allows higher doses of medication to be used, while the rest of the patient's body remains unaffected.

Temperature-sensitive

TU/e and Philips Research have been carrying out research for a number of years into methods of this kind, in which temperature-sensitive liposomes (tiny fat-based spheres) act as delivery vehicles for the medication. The liposomes contain the medication and a contrast medium that is visible in an MRI scan. After injection into the blood, the liposomes transport the medication through the body. The location of the tumor is identified using MRI, after which the tumor is warmed by means of ultrasound. When the liposomes reach the tumor, the increased temperature causes them to open so that the medication and contrast medium are released.

Slowing down tumor growth

Mariska de Smet shows the effectiveness of this method in her PhD research at TU/e, in which she was supervised by prof.dr. Holger Gr?ll. Tumor growth was found to be reduced after treatment using this technique. In fact the effect was even stronger than with regular chemotherapy. De Smet also showed that the amount of contrast agent released was a good indicator of the extent to which tumor growth was slowed down; the more contrast medium visible, the greater the effect of the chemotherapy. Because the amount of medicine released can immediately be measured, this could enable physicians in the future to quickly decide whether to administer additional medication or to start a different form of treatment.

Clinical development

The research carried out by De Smet was of a preclinical nature. Before the therapeutic effects of the method can be investigated on patients, a number of practical obstacles still need to be overcome. De Smet expects that it will take 10 -- 15 years before the new technology is available for use on patients. Mariska de Smet will gain her PhD on the 14th March at Eindhoven University of Technology for her thesis entitled 'MR-HIFU mediated local drug delivery using temperature-sensitive liposomes'. Her supervisor is prof.dr. Holger Gr?ll (TU/e and Philips Research), and her copromotor is dr. Sander Langereis (Philips Research).

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Eindhoven University of Technology.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/dPTwVQduwKQ/130313123308.htm

grapes of wrath silent house nfl mock draft project m